As a consequence of increasing average life expectancies and increasing physical activity, such as high-impact sports, our bodies constantly experience high loads, which may lead to contusions. The number of musculoskeletal injuries causing dysfunction and chronic pain, and requiring medical intervention, is constantly growing. Especially vulnerable are zones where different tissue types are in contact, […]
We are working on Melt electrowriting (MEW) of scaffolds for recapitulation of the blood-brain barrier (BBB) in dynamic on-chip cancer models. This project aims to design a thin polymeric membrane on which relevant for BBB cells to form confluent layers with tight junctions. The membrane will serve as a minimalistic supporting scaffold, favoring cell-cell interactions […]
Musculoskeletal degeneration and complications from injuries have become more prevalent as people live longer and increasingly participate in rigorous athletic and recreational activities. Especially prone to damage are so-called hard-soft tissue interfaces, such as tendon-bone interfaces. These natural interfaces are hierarchical structures with gradually changing physicochemical and biological properties. Until now, most of the clinically available regenerative […]
