This project aims to design the next generation of endobronchial valves by integrating computational modeling, experimental validation, and advanced 3D printing technologies, with a focus on mechanical performance, biocompatibility, and functional enhancement for clinical application. The newly developed valve should have superior properties compared to currently used valves, which often induce clinical problems such as excessive granulation and fibrotic tissue formation, leading to inflammation and, ultimately, the need for removal within a short period. The challenge is to achieve all these advanced features primarily through the design of the overall shape and structure of the printed elements, while also integrating functional coatings. The planned integration of MEW (Melt Electrowriting), FDM (Fused Deposition Modeling), bioprinting (in collaboration with other PhD from the program) and hydrogel coatings, requires precise coordination and optimization, that will be addressed by the student.
