Musculoskeletal degeneration and complications from injuries have become more prevalent as people live longer and increasingly participate in rigorous athletic and recreational activities. Especially prone to damage are so-called hard-soft tissue interfaces, such as tendon-bone interfaces. These natural interfaces are hierarchical structures with gradually changing physicochemical and biological properties. Until now, most of the clinically available regenerative treatments are not very successful and it is still a major challenge to produce scaffolds that closely imitate the complexity of native tissue.
Therefore, in this project I aim at developing polymeric fibrous scaffolds for musculoskeletal tissue engineering, with well controlled mechanical and biological properties.