3D printed tissue models for determining biocompatibility of metallic coatings

Metallic biomaterials are broadly used in orthopedics and dentistry. They can be utilized as bulk scaffolds or coatings, in both cases resulting in the contact of metal ions with surrounding tissues. Here, we propose printed in vitro models to study the influence of the bound and released metal ions on cell and tissue performance. 

In this work, tissue models are obtained using MEW and extrusion bioprinting and placed on the surfaces of non-toxic metal coatings, such as Ti, Ta, Zr, Ag, W, Nb. Biocompatibility, bioactivity, and antibacterial properties of the coatings are investigated. The work is divided into two main stages, combining physical vapor deposition coating technology and 3D bioprinting technology. Ultimately, the material surface-tissue interactions will be determined for different types of metals used in implants. 

Project involvement:
Taha Cagri Senocak

Funded by:
The Scientific and Technological Research Council of Turkey (TUBITAK)